Ways to Quit Nicotine Gum | Nicotine Patches | Nicotine Spray & Inhaler Zyban | Hypnosis & Acupuncture | Cold Turkey Nicotine Spray & Inhaler   Success Rate 15% to 30%     What it is: These two more recent nicotine-replacement strategies work in a similar manner to the gum and patch. Both the nasal spray and the inhaler are prescription items. How it works: The spray is placed in the nostril where it releases a controlled amount of nicotine into the system. You spray it in your nose as you would a solution to help with decongestion. The nicotine inhaler is used the same way as an asthma inhaler -- the capsule is placed in the mouth and several "puffs" of its contents are administered. Again, it provides a reduced dose of nicotine.